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Recombinant Human HVEM-Fc
Description : |
HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-beta (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a “receptor decoy” resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta. Recombinant human HVEM-Fc Chimera is a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of HVEM and a C-terminal domain corresponding to residues 102 to 330 of human IgG1. |
Catalog #: |
003-HVEMFc
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Source: |
High-5 (BTI-Tn-5B1-4) Insect Cells |
Stability: |
The lyophilized protein is stable for a few weeks at room temperature, but best stored at -200C.
Reconstituted HVEM-Fc should be stored in working aliquots at -200C. |
Purity: |
Greater than 98% by SDS-PAGE and HPLC analyses. |
Endotoxin Level: |
Endotoxin level is less than 0.1 ng per μg (1EU/μg). |
Biological Activity: |
Determined by its ability to neutralize 0.25 ng/ml of hTNFß induced cytotoxicity on murine L929 cells. The expected ED50 for this effect is 1.3-1.9 µg/ml of HVEM-Fc.
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PubMed Link : |
HVEM-Fc |
Usage: |
For research Purposes Only - Made using
a cell BTI-Tn-5B1-4 under license from the Boyce Thompson
Institute for Plant Research, Inc. Not for use in diagnostic
or therapeutic procedures.
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Country of Origin: |
USA
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