Active Soluble Fas Ligand

SBH Sciences soluble Fas Ligand is a soluble 19.9 kDa protein containing 175 amino acid residues, comprising of the extracellular domain of FasL (amino acids Leu 107 to Leu 281). The activation of our soluble form of FasL might be due to the presence of the extracellular residues 107-134, which are not expressed, in other commercial Fas Ligand. This explanation is supported by Hohlbaum et al. Soluble FasL construct is involved in multimerization of FasL in solution or on the target cell surface which is necessary for efficient activation of the caspase cascade.

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