Recombinant Human GalNAc-T16 (Polypeptide N-acetylgalactosaminyltransferase 16), soluble fragment



Polypeptide N-acetylgalactosaminyltransferase 16 (GalNAc-T16) catalyzes the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the hydroxyl group of serine and threonine residues (1).  Twenty GalNAc-T genes have been identified in humans and most have been shown to represent active GalNAc-Ts.  All isoforms are type II transmembrane proteins, with different but partly overlapping substrate preferences (2).  The GalNAc-Ts control the initiation of mucin-type O-linked glycosylation and determine the location and density of O-glycans in a protein (2).  Addition of GalNAc to an unglycosylated Ser/Thr residue creates the Tn antigen GalNAcα1-S/T, and subsequent addition of sialic acid by ST6GalNAc-I forms the cancer associated STn antigen (3). 

  1. Bennet, E.P. Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
  2. Tian, E. & Ten Hagen, K.G. (2009) Glycocon. J. 26, 325.
  3. Sewell, R. et al. (2006) J. Biol. Chem. 281, 3586.

Catalog #:  SBH-003- GalNAc-T16

Source :  Insect Cells, Accession # Q68VJ8

Formulation:  Sterile filtered solution in 25mM Tris pH7.5 and 150mM NaCl, at a stock concentration of 100 ug/mL.

Stability:  Stable for 4 weeks at 4C.  Stable for 6 months at -80C.  Avoid repeated freeze-thaw cycles.

Purity:  Greater than 90% by SDS-PAGE.

Reconstitution:  N/A

Biological Activity:  In Progess

UniProt  Link: GalNAc-T16 Human

Usage:  For research only. Not for use in diagnostic or therapeutic procedures.

Country of Origin:  USA

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