SBH Offers ELLA Platform for COVID-19 and Cytokine-storm Research

(Natick, MA)  April 10, 2020. As the world continues to fight the global SARS-CoV-2 pandemic, SBH Sciences and SBH Diagnostics would like to extend a helping hand to those looking to detect the SARS-CoV-2 virus in patient samples. SBH Sciences / Diagnostics biomarker department has been measuring cytokines and other biomarkers for 20 years and is well equipped to detect elevated cytokine levels, more commonly known as a cytokine storm. A cytokine storm is an excessive and unhindered pro-inflammatory immune response to a new infection, be it bacterial or viral in nature, that can lead to damage of vital organs and in severe or misdiagnosed cases, multiple organ failure and subsequent death. Cytokine storms have emerged at the forefront of the discussion concerning the surprising mortality rate of young, seemingly-healthy individuals diagnosed with SARS-CoV-2.

SBH Sciences and SBH Diagnostics can offer a few different laboratory services directed at identifying patients that may be suffering from this condition. A patient’s inflammatory response to this virus can be measured in real time utilizing the ELLA™ platform from ProteinSimple and their new Simple Plex COVID-19 Cytokine Storm and Simple Plex Multiplex Cytokine Screening panels. These panels allow for the analysis of some of the most prevalent pro-inflammatory cytokines associated with cytokine storms; IL-1 βeta, IL-6, IL-8, and TNF-αlpha. This system can test up to 32 patient samples in under 2 hours. This real-time testing can detect elevated levels of these cytokines quickly and reliably, allowing patients who are experiencing this undesirable immune response to receive the treatment they need before their symptoms are allowed to take a turn for the worst. This testing could also be beneficial for the monitoring of patient responses to experimental drugs that are currently being tested for use in mitigating the effects of cytokine storms. SBH has validated these analytes on the ELLA platform previously and has worked with all of these analytes in the past.

Additionally, SBH Sciences and SBH Diagnostics has validated over 30 cytokines, including all of those listed above, on the Luminex 200 instrument and can utilize that instrument for same day testing of numerous pro-inflammatory cytokines heavily associated with cytokine storms. The Luminex panels can be customized if there are any additional cytokines that are specifically required.

About SBH Sciences, Inc.
SBH Sciences is an innovative pre-clinical contract research organization focused on anti-cancer and anti-inflammatory drug development. The company is the world leader with over 300 cell-based assays to measure biological activity of cytokines and growth factors. The availability of 350 human cancer cell lines enables in-vitro lead compounds screening. Combined with the production of 80 biological and 10 innovative platforms for biomarker analysis, SBH has assisted over 240 biotechnology companies in the last 22 years, to advance their research programs toward clinical trials. For further information, please contact SBHsciences.com



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